Kisspeptin-10 : Le peptide de fertilité et libido émergeant des essais cliniques
Novo Pharma Research Team
Recherche Novo Pharma · synthèse de littérature révisée par les pairs
Kisspeptin-10 : Le peptide de fertilité et libido émergeant des essais cliniques
Meta Description : Kisspeptin-10 est le régulateur maître de l'axe HPG maintenant en essais cliniques pour la fertilité, la libido et l'hypogonadisme. Découvrez les mécanismes, les dosages et le potentiel pour la PCT.
Références :
- de Roux N, et al. Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54. Proc Natl Acad Sci USA. 2003;100(19):10972-10976.
- Seminara SB, et al. The GPR54 gene as a regulator of puberty. N Engl J Med. 2003;349(17):1614-1627.
- Kotani M, et al. The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54. J Biol Chem. 2001;276(37):34631-34636.
- Navarro VM, Tena-Sempere M. Neuroendocrine control by kisspeptins: role in metabolic regulation of fertility. Nat Rev Endocrinol. 2012;8(1):40-53.
- Oakley AE, et al. Kisspeptin signaling in the brain. Endocr Rev. 2009;30(6):713-743.
- Comninos AN, et al. Kisspeptin modulates sexual and emotional brain processing in humans. J Clin Invest. 2017;127(2):709-719.
- Mills EG, et al. Kisspeptin enhances brain responses to olfactory and visual cues of attraction in women. JAMA Netw Open. 2022;5(6):e2216396.
- Abbara A, et al. Efficacy of kisspeptin-54 to trigger oocyte maturation in women at high risk of ovarian hyperstimulation syndrome (OHSS) during in vitro fertilization (IVF) therapy. J Clin Endocrinol Metab. 2015;100(9):3322-3331.
- Jayasena CN, et al. Kisspeptin-54 triggers egg maturation in women undergoing in vitro fertilization. J Clin Invest. 2014;124(8):3667-3677.
- Dhillo WS, et al. Kisspeptin-54 stimulates the hypothalamic-pituitary gonadal axis in human males. J Clin Endocrinol Metab. 2005;90(12):6609-6615.
- Smith JT, et al. Regulation of Kiss1 gene expression in the brain of the female mouse. Endocrinology. 2006;147(3):1159-1166.
- Seminara SB, et al. Continuous human metastin 45-54 infusion desensitizes G protein-coupled receptor 54-induced gonadotropin-releasing hormone release monitored indirectly in the juvenile male Rhesus monkey. Endocrinology. 2006;147(5):2122-2126.
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