Mitochondria Stack
MOTS-c + SS-31 — cellular energy production attacked from both ends.
Overview
The two flagship mitochondrial peptides in one protocol. MOTS-c is a mitochondrial-derived peptide that activates AMPK — the cell's master metabolic switch — improving insulin sensitivity, exercise capacity, and fat oxidation. SS-31 (Elamipretide) works structurally: it binds cardiolipin on the inner mitochondrial membrane, stabilizing the electron transport chain and reducing reactive oxygen species. One improves the signal, the other repairs the machinery.
Who it's for
- 01Researchers focused on metabolic health, endurance, and healthspan
- 02Athletes in high-volume training blocks chasing recovery capacity
- 0340+ researchers targeting age-related mitochondrial decline
What's inside — 2 compounds
$50.00
View PDP →- Dose
- 5 mg
- Frequency
- 2× weekly
- Weeks
- 1-8
- Category
- peptides
Subcutaneous, morning of training days.
$63.00
View PDP →- Dose
- 2 mg
- Frequency
- Daily
- Weeks
- 1-8
- Category
- peptides
Subcutaneous, any consistent time of day.
Weekly Protocol
Both peptides run the full 8 weeks. Effects are cumulative rather than acute — week 1 feels like nothing, week 4 is where capacity changes show. Pair with zone-2 cardio for compounding mitochondrial adaptation. An 8-week off period before repeating is standard practice.
| Compound | Dose | Frequency | Weeks |
|---|---|---|---|
| MOTS-c | 5 mg | 2× weekly | 1-8 |
| SS-31 | 2 mg | Daily | 1-8 |
Expected Outcomes
- Improved exercise capacity and reduced fatigue within 2–3 weeks
- Better fasting glucose and insulin sensitivity markers
- Subjective energy improvement — most reported with SS-31
- No hormonal suppression — both peptides are non-endocrine
Support Requirements
Items referenced in the protocol. Some are included in the stack; support-only items may need to be ordered separately.
Reconstitution of both lyophilized peptides
Subcutaneous administration
Safety & Warnings
- Human data for both compounds is early-stage — treat as investigational.
- MOTS-c may transiently lower blood glucose — caution if hypoglycemia-prone.
- Refrigerate both peptides after reconstitution; use within 30 days.
Frequently Asked
Will I feel this like a stimulant?
No. There is no acute 'kick' — these change how your cells produce energy, not how your nervous system perceives it. The signature is less fatigue at the same workload, measured over weeks.
Can I run this alongside a fat-loss or muscle protocol?
Yes — neither peptide touches the androgen or GH axes, so it layers cleanly under almost any other stack. It's most synergistic with endurance work and caloric deficits.
Research disclaimer
All stack suggestions reflect the published literature and are provided for research-reference purposes only. Individual protocols require compound-specific planning. Consult the stacking theory guide before designing your protocol. Not medical advice.