TB-500 for Tendon & Ligament Repair: What the Research Shows
TB-500 (Thymosin Beta-4) promotes tendon and ligament healing through cell migration, angiogenesis, and inflammation reduction. Learn the research-backed loading protocol (2-2.5mg 2x/week), injection method, and recovery timeline.
Novo Pharma Research Team
Novo Pharma Research · peer-reviewed literature synthesis
TB-500 for Tendon & Ligament Repair: What the Research Shows
References:
- Goldstein AL, et al. Thymosin beta4: actin-sequestering protein moonlights to repair injured tissues. Trends Mol Med. 2005;11(9):421-429. PMID: 16099219
- Philp D, et al. Thymosin beta 4 promotes angiogenesis, wound healing, and hair follicle development. Mech Ageing Dev. 2004;125(2):113-115. PMID: 15037011
- Smart N, et al. Thymosin beta4 induces adult epicardial progenitor mobilization and neovascularization. Nature. 2007;445(7124):177-182. PMID: 17108969
- Sosne G, et al. Thymosin beta 4 promotes corneal wound healing and decreases inflammation in vivo following alkali injury. Exp Eye Res. 2002;74(2):293-299. PMID: 11950239
- Malinda KM, et al. Thymosin beta4 accelerates wound healing. J Invest Dermatol. 1999;113(3):364-368. PMID: 10469334
- Ehrlich HP, Bhagavan NV. The effect of thymosin beta-4 on cell composition and collagen in carrageenan-induced granuloma pouches. Proc Soc Exp Biol Med. 1991;196(3):300-304. PMID: 1998007
- Dowling BA, et al. Recombinant equine growth hormone does not affect biomechanical properties of the superficial digital flexor tendon in standardbred horses in training. Vet Surg. 2002;31(1):61-66. PMID: 11778169
- Ruff D, et al. Thymosin Beta-4 for the treatment of non-healing venous stasis ulcers: results of a Phase II study. J Invest Dermatol. 2010;130:S82.
- Treadwell T, et al. The regenerative properties of thymosin β4 in the treatment of sports injuries and wound care. Expert Opin Biol Ther. 2018;18(sup1):131-138. PMID: 30063872
- Kleinman HK, Sosne G. Thymosin beta 4 and the potential for use in cancer therapy. Ann N Y Acad Sci. 2016;1374(1):96-102. PMID: 27333077
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