Kisspeptin-10: The Fertility & Libido Peptide Emerging from Clinical Trials
Kisspeptin-10 is the master HPG axis regulator now in clinical trials for fertility, libido, and hypogonadism. Learn mechanisms, dosing, and PCT potential.
Novo Pharma Research Team
Novo Pharma Research · peer-reviewed literature synthesis
Kisspeptin-10: The Fertility & Libido Peptide Emerging from Clinical Trials
References:
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- Kotani M, et al. The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54. J Biol Chem. 2001;276(37):34631-34636.
- Navarro VM, Tena-Sempere M. Neuroendocrine control by kisspeptins: role in metabolic regulation of fertility. Nat Rev Endocrinol. 2012;8(1):40-53.
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- Abbara A, et al. Efficacy of kisspeptin-54 to trigger oocyte maturation in women at high risk of ovarian hyperstimulation syndrome (OHSS) during in vitro fertilization (IVF) therapy. J Clin Endocrinol Metab. 2015;100(9):3322-3331.
- Jayasena CN, et al. Kisspeptin-54 triggers egg maturation in women undergoing in vitro fertilization. J Clin Invest. 2014;124(8):3667-3677.
- Dhillo WS, et al. Kisspeptin-54 stimulates the hypothalamic-pituitary gonadal axis in human males. J Clin Endocrinol Metab. 2005;90(12):6609-6615.
- Smith JT, et al. Regulation of Kiss1 gene expression in the brain of the female mouse. Endocrinology. 2006;147(3):1159-1166.
- Seminara SB, et al. Continuous human metastin 45-54 infusion desensitizes G protein-coupled receptor 54-induced gonadotropin-releasing hormone release monitored indirectly in the juvenile male Rhesus monkey. Endocrinology. 2006;147(5):2122-2126.
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