Humanin: The Brain-Protecting Peptide for Cognitive Aging

Humanin peptide protects neurons from Alzheimer's-related damage. Discover its neuroprotective mechanisms, metabolic benefits, dosing research & longevity potential.

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Novo Pharma Research Team

Novo Pharma Research · peer-reviewed literature synthesis

15 min read
humanin peptidehumanin neuroprotectionhumanin Alzheimershumanin longevityhumanin cognitive

Humanin: The Brain-Protecting Peptide for Cognitive Aging

References

  1. Hashimoto Y, et al. A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Aβ. Proc Natl Acad Sci USA. 2001;98(11):6336-6341.
  2. Alzheimer Society of Canada. Dementia numbers in Canada. 2024 report.
  3. Lee C, et al. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metab. 2015;21(3):443-454.
  4. Niikura T, et al. Humanin: a peptide making a case for Alzheimer's disease therapeutics. Peptides. 2006;27(4):943-956.
  5. Guo B, et al. Humanin peptide suppresses apoptosis by interfering with Bax activation. Nature. 2003;423(6938):456-461.
  6. Ikonen M, et al. Interaction between the Alzheimer's survival peptide humanin and insulin-like growth factor-binding protein 3 (IGFBP-3) regulates cell survival and apoptosis. Proc Natl Acad Sci USA. 2003;100(22):13042-13047.
  7. Hashimoto Y, et al. Humanin inhibits neuronal cell death by interacting with a cytokine receptor complex or complexes involving CNTF receptor alpha/WSX-1/gp130. Mol Biol Cell. 2009;20(12):2864-2873.
  8. Tajima H, et al. Evidence for in vivo production of Humanin peptide, a neuroprotective factor against Alzheimer's disease-related insults. Neurosci Lett. 2002;324(3):227-231.
  9. Niikura T, et al. A humanin derivative reduces amyloid beta accumulation and ameliorates memory deficit in triple transgenic mice. PLoS One. 2011;6(1):e16259.
  10. Thummasorn S, et al. Humanin directly protects cardiac mitochondria against dysfunction initiated by oxidative stress. J Mol Med. 2018;96(3):231-242.
  11. Muzumdar RH, et al. Humanin: a novel central regulator of peripheral insulin action. PLoS One. 2009;4(7):e6334.
  12. Bachar AR, et al. Humanin is expressed in human vascular walls and has a cytoprotective effect against oxidized LDL-induced oxidative stress. Cardiovasc Res. 2010;88(2):360-366.
  13. Yen K, et al. Humanin prevents age-related cognitive decline in mice and is associated with improved cognitive age in humans. Sci Rep. 2018;8(1):14212.
  14. Lee C, et al. Humanin and caloric restriction. Aging. 2014;6(7):539-541.
  15. Moretti E, et al. Humanin and cancer: a dual role? Int J Mol Sci. 2018;19(5):1530.
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